STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nr1h4Protein phosphatase 5, catalytic subunit. (458 aa)    
Predicted Functional Partners:
ppargc1a
LETM1 domain-containing protein LETM2, mitochondrial.
   
 
 0.883
gpbar1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.728
xpr1
Xenotropic and polytropic retrovirus receptor 1 homolog; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
      
 0.722
cyp7a1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 
 0.716
fgf19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 
 0.699
rxrg
Glutamate receptor interacting protein 2.
   
 
0.673
rxra
Paralemmin.
   
 
0.673
rxrb
Uncharacterized protein.
   
 
0.673
ncor1
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Participates in complexes which promote histone deacetylation and the formation of repressive chromatin structures which may impede access by the basal transcription machinery (By similarity). In association with hdac3, may play a role in the regulation of the circadian clock (By similarity).
    
 
 0.671
ncor2
EPH receptor A4.
    
 
 0.671
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.