STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wnk3Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)    
Predicted Functional Partners:
RAPGEF4
Rap guanine nucleotide exchange factor 4.
   
 
 0.931
prkaca
Integrator complex subunit 8; Belongs to the protein kinase superfamily.
    
 0.927
prkacb
Uncharacterized protein; Belongs to the protein kinase superfamily.
    
 0.927
calm2
Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.
    
 0.921
birc5
Baculoviral IAP repeat-containing protein 5.1.
   
 
 0.920
gnai3
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.
   
 0.919
gnai1
Uncharacterized protein.
   
 0.919
ptrhd1
Inactive serine protease PAMR1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
     
0.911
ITPA
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.
    
 0.908
calml4
Calmodulin-like protein 4; Belongs to the calmodulin family.
     
 0.907
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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