STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ackr3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (361 aa)    
Predicted Functional Partners:
cxcl12
Stromal cell-derived factor 1; Chemoattractant. Activates the C-X-C chemokine receptor cxcr4 to induce a rapid and transient rise in the level of intracellular calcium ions, and chemotaxis. Signaling with cxcr4 mediates the directional movement of mesodermal cells during gastrulation. Binds to the allosteric site (site 2) of integrins and activates them in a cxcr4-independent manner.
    
 0.992
cxcr4
C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular calcium ion level. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs). May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity).
    
 
0.774
atp5po
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.
    
   0.569
atp5f1a
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.
    
   0.569
adm
Growth differentiation factor 3.
      
 0.539
ARRB1
Arrestin beta 1.
    
 
 0.500
arr3
Arrestin_C domain-containing protein.
    
 
 0.500
arrb2
Arrestin_C domain-containing protein.
    
 
 0.500
sag
S-antigen; retina and pineal gland (Arrestin).
    
 
 0.494
atp5f1b
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
    
   0.470
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.