node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDH05377.1 | SDH07468.1 | SAMN05660652_01114 | SAMN05660652_01160 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Citrate synthase; Belongs to the citrate synthase family. | 0.972 |
SDH05377.1 | SDH08248.1 | SAMN05660652_01114 | SAMN05660652_01178 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Aconitase; Belongs to the aconitase/IPM isomerase family. | 0.759 |
SDH05377.1 | SDI25668.1 | SAMN05660652_01114 | SAMN05660652_03131 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.658 |
SDH05377.1 | SDI57327.1 | SAMN05660652_01114 | SAMN05660652_03664 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.607 |
SDH05377.1 | SDI66882.1 | SAMN05660652_01114 | SAMN05660652_03832 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.427 |
SDH05377.1 | SDI66936.1 | SAMN05660652_01114 | SAMN05660652_03833 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Dihydrolipoamide dehydrogenase. | 0.607 |
SDH05377.1 | SDI73530.1 | SAMN05660652_01114 | SAMN05660652_03961 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.658 |
SDH05377.1 | mdh | SAMN05660652_01114 | SAMN05660652_01162 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.991 |
SDH05377.1 | ppc | SAMN05660652_01114 | SAMN05660652_03984 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.788 |
SDH05377.1 | sucC | SAMN05660652_01114 | SAMN05660652_02382 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.916 |
SDH07468.1 | SDH05377.1 | SAMN05660652_01160 | SAMN05660652_01114 | Citrate synthase; Belongs to the citrate synthase family. | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.972 |
SDH07468.1 | SDH08248.1 | SAMN05660652_01160 | SAMN05660652_01178 | Citrate synthase; Belongs to the citrate synthase family. | Aconitase; Belongs to the aconitase/IPM isomerase family. | 0.977 |
SDH07468.1 | SDI25668.1 | SAMN05660652_01160 | SAMN05660652_03131 | Citrate synthase; Belongs to the citrate synthase family. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.987 |
SDH07468.1 | SDI57327.1 | SAMN05660652_01160 | SAMN05660652_03664 | Citrate synthase; Belongs to the citrate synthase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.976 |
SDH07468.1 | SDI66882.1 | SAMN05660652_01160 | SAMN05660652_03832 | Citrate synthase; Belongs to the citrate synthase family. | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.977 |
SDH07468.1 | SDI66936.1 | SAMN05660652_01160 | SAMN05660652_03833 | Citrate synthase; Belongs to the citrate synthase family. | Dihydrolipoamide dehydrogenase. | 0.988 |
SDH07468.1 | SDI73530.1 | SAMN05660652_01160 | SAMN05660652_03961 | Citrate synthase; Belongs to the citrate synthase family. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.986 |
SDH07468.1 | mdh | SAMN05660652_01160 | SAMN05660652_01162 | Citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.995 |
SDH07468.1 | ppc | SAMN05660652_01160 | SAMN05660652_03984 | Citrate synthase; Belongs to the citrate synthase family. | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.944 |
SDH07468.1 | sucC | SAMN05660652_01160 | SAMN05660652_02382 | Citrate synthase; Belongs to the citrate synthase family. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.978 |