STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUMBLNUMB like, endocytic adaptor protein. (599 aa)    
Predicted Functional Partners:
NOTCH1
Notch 1.
   
 0.971
NOTCH4
Notch 4.
    
 0.944
NUMB
NUMB, endocytic adaptor protein.
  
  
 
0.902
ITCH
E3 ubiquitin-protein ligase Itchy.
    
 0.798
MDM2
E3 ubiquitin-protein ligase Mdm2.
    
 
 0.775
AP2A1
Adaptor related protein complex 2 subunit alpha 1.
    
 0.749
NOTCH2
Notch receptor 2.
   
 0.705
LNX1
Ligand of Numb protein X 1/2.
   
 
 0.691
BMP2K
BMP2 inducible kinase.
    
 
 0.660
JAG1
Jagged 1.
   
 0.651
Your Current Organism:
Equus asinus
NCBI taxonomy Id: 83772
Other names: E. asinus asinus, Equus asinus asinus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.