STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LEPRLeptin receptor. (1166 aa)    
Predicted Functional Partners:
LEP
Leptin.
    
 0.999
JAK2
Janus kinase 2.
    
 0.995
SOCS3
Suppressor of cytokine signaling 3.
    
 0.986
POMC
Proopiomelanocortin.
      
 0.972
AGRP
Agouti related neuropeptide.
      
 0.967
NPY
Neuropeptide Y.
      
 0.960
INS
Insulin.
      
 0.914
MC4R
Melanocortin 4 receptor.
      
 0.867
TYK2
Non-receptor tyrosine-protein kinase TYK2.
    
 0.864
IL7
Interleukin 7.
     
 0.851
Your Current Organism:
Equus asinus
NCBI taxonomy Id: 83772
Other names: E. asinus asinus, Equus asinus asinus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.