STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN11Protein tyrosine phosphatase, non-receptor type 11. (593 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-binding protein 2.
   
0.999
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.997
EGFR
Epidermal growth factor receptor.
    
 0.994
GAB1
GRB2 associated binding protein 1.
    
 0.992
IRS1
Insulin receptor substrate 1.
    
 0.991
JAK2
Janus kinase 2.
   
 0.986
PIK3R1
Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.
    
 0.985
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.982
PDGFRB
Platelet derived growth factor receptor beta.
   
 0.981
KIT
KIT proto-oncogene receptor tyrosine kinase.
   
 0.978
Your Current Organism:
Equus asinus
NCBI taxonomy Id: 83772
Other names: E. asinus asinus, Equus asinus asinus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.