STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN6Protein tyrosine phosphatase, non-receptor type 6. (597 aa)    
Predicted Functional Partners:
CD22
CD22 molecule.
   
 0.991
SYK
Spleen associated tyrosine kinase.
   
 0.984
ZAP70
Tyrosine-protein kinase ZAP-70.
   
0.972
JAK2
Janus kinase 2.
   
 0.965
CD247
CD3Z antigen, zeta polypeptide.
   
 0.965
JAK1
Janus kinase 1.
   
 0.958
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.952
TYK2
Non-receptor tyrosine-protein kinase TYK2.
   
 0.943
PIK3R3
Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.
    
 0.941
PIK3R1
Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.
    
 0.941
Your Current Organism:
Equus asinus
NCBI taxonomy Id: 83772
Other names: E. asinus asinus, Equus asinus asinus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.