STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (507 aa)    
Predicted Functional Partners:
SEA53755.1
Acetolactate synthase, small subunit.
 
 
 0.982
SEA80819.1
L-threonine synthase.
 
 
 0.978
SEA55248.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
  
 0.961
SEA53777.1
Acetolactate synthase, large subunit.
  
 0.961
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.939
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.934
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.932
SEA79416.1
Threonine dehydratase.
  
  
 
0.929
SEB19441.1
L-serine/L-threonine ammonia-lyase.
  
  
 
0.928
SEB02756.1
Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family.
  
 0.925
Your Current Organism:
Paraburkholderia sartisoli
NCBI taxonomy Id: 83784
Other names: Burkholderia sartisoli, Burkholderia sartisoli Vanlaere et al. 2008, Burkholderia sp. LMG 22948, Burkholderia sp. R-701, Burkholderia sp. RG6-9, Burkholderia sp. RP007, CCUG 53604, ICMP 13529, LMG 24000, LMG:24000, P. sartisoli, Paraburkholderia sartisoli (Vanlaere et al. 2008) Sawana et al. 2015, strain RP 007, strain RP007
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