STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topBDNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (728 aa)    
Predicted Functional Partners:
recQ
ATP-dependent DNA helicase RecQ.
 0.977
nifJ2
Pyruvate-flavodoxin oxidoreductase NifJ.
  
   0.937
AKL94311.1
Single-strand binding protein/primosomal replication protein n.
 
 
 0.931
ssb3
Single-stranded DNA-binding protein 3.
  
 
 0.922
leuS
leucyl-tRNA synthetase LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.919
nifJ1
Pyruvate-flavodoxin oxidoreductase NifJ.
  
   0.913
AKL94192.1
Glutamate synthase (NADPH/NADH) large chain.
  
  
 0.884
gltA
Glutamate synthase ferredoxin dependend large subunit.
  
  
 0.884
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.868
polA-2
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.854
Your Current Organism:
Clostridium aceticum
NCBI taxonomy Id: 84022
Other names: ATCC 35044, C. aceticum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.