STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ROHU_006097WW domain-containing transcription regulator 1. (447 aa)    
Predicted Functional Partners:
ROHU_026096
Serine threonine-kinase LATS1.
    
 0.967
ROHU_007844
Serine threonine-kinase LATS2-like protein.
    
 0.966
ROHU_006801
Serine threonine-kinase 3.
    
 0.959
ROHU_010908
Transcriptional enhancer factor TEF-1-like protein.
   
 0.956
ROHU_036987
Transcriptional enhancer factor TEF-1 isoform X1.
   
 0.956
ROHU_025957
Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
   
 0.956
ROHU_019524
Angiomotin-like isoform X1.
    
 0.916
ROHU_015372
Angiomotin 1.
    
 0.902
ROHU_029448
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.901
ROHU_025747
Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
    
 0.901
Your Current Organism:
Labeo rohita
NCBI taxonomy Id: 84645
Other names: Cyprinus rohita, Jayanti rohu, L. rohita, rohu
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