node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCK | INS | M7BKE0 | M7BBB7 | Cholecystokinin. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.688 |
CCK | LEP | M7BKE0 | M7BYR5 | Cholecystokinin. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | 0.676 |
CCK | UY3_04041 | M7BKE0 | M7CD79 | Cholecystokinin. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.582 |
CCK | UY3_13816 | M7BKE0 | M7AWG0 | Cholecystokinin. | Pro-opiomelanocortin A. | 0.674 |
CCK | UY3_19114 | M7BKE0 | M7AVQ3 | Cholecystokinin. | Pro-neuropeptide Y. | 0.787 |
INS | CCK | M7BBB7 | M7BKE0 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Cholecystokinin. | 0.688 |
INS | LEP | M7BBB7 | M7BYR5 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | 0.791 |
INS | PPARG | M7BBB7 | M7BNQ1 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.637 |
INS | STAT3 | M7BBB7 | M7CHU4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Signal transducer and activator of transcription. | 0.483 |
INS | UY3_04041 | M7BBB7 | M7CD79 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.541 |
INS | UY3_10457 | M7BBB7 | M7B9Z4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Leptin receptor. | 0.485 |
INS | UY3_11506 | M7BBB7 | M7BTB6 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Adiponectin. | 0.708 |
INS | UY3_13816 | M7BBB7 | M7AWG0 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Pro-opiomelanocortin A. | 0.646 |
INS | UY3_19114 | M7BBB7 | M7AVQ3 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Pro-neuropeptide Y. | 0.487 |
LEP | CCK | M7BYR5 | M7BKE0 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Cholecystokinin. | 0.676 |
LEP | INS | M7BYR5 | M7BBB7 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.791 |
LEP | PPARG | M7BYR5 | M7BNQ1 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.741 |
LEP | SOCS3 | M7BYR5 | M7BA47 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Suppressor of cytokine signaling 3. | 0.627 |
LEP | STAT3 | M7BYR5 | M7CHU4 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Signal transducer and activator of transcription. | 0.679 |
LEP | UY3_04041 | M7BYR5 | M7CD79 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.714 |