node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEX1 | MSH6 | M7AIU0 | M7BSE6 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.514 |
APEX1 | MUTYH | M7AIU0 | M7C113 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.784 |
APEX1 | NTHL1 | M7AIU0 | M7BMG7 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.989 |
APEX1 | UNG | M7AIU0 | M7BN56 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.802 |
APEX1 | UY3_12361 | M7AIU0 | M7B0G5 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.845 |
MSH6 | APEX1 | M7BSE6 | M7AIU0 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.514 |
MSH6 | MUTYH | M7BSE6 | M7C113 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.662 |
MSH6 | NTHL1 | M7BSE6 | M7BMG7 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.514 |
MSH6 | UNG | M7BSE6 | M7BN56 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.761 |
MSH6 | UY3_00848 | M7BSE6 | M7BVP4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.400 |
MSH6 | UY3_12361 | M7BSE6 | M7B0G5 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.990 |
MUTYH | APEX1 | M7C113 | M7AIU0 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.784 |
MUTYH | MSH6 | M7C113 | M7BSE6 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.662 |
MUTYH | NEIL3 | M7C113 | M7AW45 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Endonuclease 8-like 3. | 0.696 |
MUTYH | NTHL1 | M7C113 | M7BMG7 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.686 |
MUTYH | UNG | M7C113 | M7BN56 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.677 |
MUTYH | UY3_00848 | M7C113 | M7BVP4 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.968 |
MUTYH | UY3_11682 | M7C113 | M7BSQ5 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Bifunctional aminoacyl-tRNA synthetase. | 0.686 |
MUTYH | UY3_12361 | M7C113 | M7B0G5 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.788 |
MUTYH | UY3_14496 | M7C113 | M7BJN4 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Uncharacterized protein. | 0.758 |