STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POU4F1POU domain, class 4, transcription factor 1. (98 aa)    
Predicted Functional Partners:
UY3_01613
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.451
SIX6
Homeobox protein SIX6.
  
   
 0.421
NKX6-3
Homeobox protein Nkx-6.3.
   
  
 0.421
UBLCP1
Ubiquitin-like domain-containing CTD phosphatase 1.
      
 0.418
CHMP2B
Charged multivesicular body protein 2b.
      
 0.400
LRRN1
Leucine-rich repeat neuronal protein 1.
      
 0.400
NDNF
Fibronectin type-III domain-containing protein C4orf31.
      
 0.400
Your Current Organism:
Chelonia mydas
NCBI taxonomy Id: 8469
Other names: C. mydas, Chelonia midas, Chelonia mydas caranigra, Green sea turtle, Testudo mydas, green seaturtle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.