node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARQ46812.1 | rluB_2 | BRW83_2075 | BRW83_2071 | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.539 |
ARQ46812.1 | rsmI_2 | BRW83_2075 | BRW83_2107 | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | Ribosomal RNA small subunit methyltransferase I. | 0.516 |
cmk | der | BRW83_0467 | BRW83_2084 | Cytidylate kinase. | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.971 |
cmk | rluB_2 | BRW83_0467 | BRW83_2071 | Cytidylate kinase. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.439 |
der | cmk | BRW83_2084 | BRW83_0467 | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Cytidylate kinase. | 0.971 |
der | rlmB_1 | BRW83_2084 | BRW83_0790 | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB. | 0.409 |
der | rluB_2 | BRW83_2084 | BRW83_2071 | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.605 |
efp | map | BRW83_1050 | BRW83_2069 | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.662 |
efp | rluB_2 | BRW83_1050 | BRW83_2071 | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.569 |
exoA | rluB_2 | BRW83_0403 | BRW83_2071 | Exodeoxyribonuclease. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.422 |
exoA | xthA | BRW83_0403 | BRW83_2026 | Exodeoxyribonuclease. | Exodeoxyribonuclease III. | 0.928 |
glnD | map | BRW83_2070 | BRW83_2069 | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.794 |
glnD | rluB_2 | BRW83_2070 | BRW83_2071 | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.713 |
map | efp | BRW83_2069 | BRW83_1050 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.662 |
map | glnD | BRW83_2069 | BRW83_2070 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.794 |
map | rluB_2 | BRW83_2069 | BRW83_2071 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.699 |
rlmB_1 | der | BRW83_0790 | BRW83_2084 | 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB. | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.409 |
rlmB_1 | rluB_2 | BRW83_0790 | BRW83_2071 | 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB. | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.412 |
rluB_2 | ARQ46812.1 | BRW83_2071 | BRW83_2075 | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Hypothetical protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family. | 0.539 |
rluB_2 | cmk | BRW83_2071 | BRW83_0467 | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Cytidylate kinase. | 0.439 |