Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PSENENPresenilin enhancer gamma-secretase subunit. (101 aa)    
Predicted Functional Partners:
PSEN1
Presenilin 1.
    
 0.999
PSEN2
Presenilin 2.
    
 0.999
NCSTN
Nicastrin.
    
 0.999
ENSCPBP00000034494
Gamma-secretase subunit Aph-1b-like.
    
 0.989
APH1A
Aph-1 homolog A, gamma-secretase subunit.
    
 0.988
APH1B
Aph-1 homolog B, gamma-secretase subunit.
    
 0.973
NOTCH1
Notch 1.
    
 0.966
NOTCH2
Notch 2.
    
 0.903
NOTCH4
Notch 4.
    
 0.902
NOTCH3
Neurogenic locus notch homolog protein 2.
    
 0.902
Your Current Organism:
Chrysemys picta
NCBI taxonomy Id: 8478
Other names: C. picta bellii, Chrysemys picta bellii, Chrysemys picta subsp. bellii, western painted turtle
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.