Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MDM4MDM4, p53 regulator. (477 aa)    
Predicted Functional Partners:
TP53
Tumor protein p53.
   
 0.998
MDM2
E3 ubiquitin-protein ligase Mdm2.
    
 0.997
ATM
ATM serine/threonine kinase.
   
 0.979
TP73
Tumor protein p73.
    
 0.967
USP7
Ubiquitin carboxyl-terminal hydrolase 7.
    
 0.948
RB1
Retinoblastoma-associated protein.
   
 0.924
CSNK1A1
Casein kinase 1 alpha 1.
   
 
 0.907
TP63
Tumor protein p63.
    
 0.907
CHEK2
Serine/threonine-protein kinase CHEK2.
    
 0.902
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta.
   
 
 0.899
Your Current Organism:
Chrysemys picta
NCBI taxonomy Id: 8478
Other names: C. picta bellii, Chrysemys picta bellii, Chrysemys picta subsp. bellii, western painted turtle
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