STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIK3Serine/threonine-protein kinase SIK3. (575 aa)    
Predicted Functional Partners:
BRSK1-2
Uncharacterized protein.
 
  
  0.739
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      
 0.659
NALCN-2
Uncharacterized protein.
     
 0.652
NALCN
Sodium leak channel non-selective protein.
     
 0.652
MCM2
DNA helicase; Belongs to the MCM family.
    
 
 0.523
COL2A1
Fibrillar collagen NC1 domain-containing protein.
    
 0.512
THRA
Thyroid hormone receptor alpha.
    
 
 0.508
SCGN
Secretagogin.
   
 0.497
MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform B.
   
 0.493
HCRT
Orexin.
     
 0.488
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.