STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform A. (1572 aa)    
Predicted Functional Partners:
GADD45G
Growth arrest and DNA damage-inducible protein GADD45 gamma.
    
 0.974
MAP2K3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
0.950
MAP2K6
Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
0.950
GADD45B
Growth arrest and DNA damage-inducible protein GADD45 beta.
    
 0.949
MAP3K3-2
Uncharacterized protein.
    
0.927
ACAA1
3-ketoacyl-CoA thiolase, peroxisomal isoform B.
    
0.925
GADD45A
Growth arrest and DNA damage-inducible protein GADD45 alpha.
     
  0.900
CHAC2
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
      
 0.727
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.
   
 
0.710
MAP2K1-2
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 
0.704
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.