STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CORO2ACoronin; Belongs to the WD repeat coronin family. (480 aa)    
Predicted Functional Partners:
DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial.
      0.730
EPHX2
Bifunctional epoxide hydrolase 2.
    
 0.684
DHFR
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
    
 0.627
FPGS
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
    
 0.565
ACTR2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
   
 
 0.550
IQGAP2
Ras GTPase-activating-like protein IQGAP2.
   
 
 0.533
RFK
Riboflavin kinase.
  
 
 0.506
PAK2-2
Non-specific serine/threonine protein kinase.
    
 
 0.497
RHOG
Rho-related GTP-binding protein RhoG.
   
 
 0.496
PAK7
Serine/threonine-protein kinase PAK 7 isoform B.
    
 
 0.491
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.