Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
NUAK2Protein kinase domain-containing protein. (615 aa)    
Predicted Functional Partners:
STK11
Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily.
    
 0.704
BTRC
F-box/WD repeat-containing protein 1A isoform B.
    
   0.703
ARHGEF17
Rho guanine nucleotide exchange factor 17 isoform A.
      
 0.654
USP9X
Putative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family.
    
 
 0.650
Y1Q_0004859
Uncharacterized protein.
    
   0.643
TNS3
Tensin-3 isoform E.
      
 0.608
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
      
 0.590
MED20
Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.584
PTPN14
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
      
 0.584
PCSK9
Proprotein convertase subtilisin/kexin type 9.
      
 0.574
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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