Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CD276CD276 antigen isoform A. (338 aa)    
Predicted Functional Partners:
Y1Q_0023424
Ig-like domain-containing protein.
     
 
0.900
CLPP
ATP-dependent Clp protease proteolytic subunit.
      
 0.699
CD4
T-cell surface glycoprotein CD4.
      
 0.698
CTLA4
Cytotoxic T-lymphocyte protein 4.
      
 0.630
CD40
Tumor necrosis factor receptor superfamily member 5.
    
 0.626
PDCD1
Programmed cell death protein 1.
      
 0.586
TNFRSF9
Tumor necrosis factor receptor superfamily member 9.
      
 0.580
TNFRSF18L
Tumor necrosis factor receptor superfamily member 4 isoform C.
   
  
 0.580
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      
 0.580
Y1Q_0021296
Uncharacterized protein.
      
 0.554
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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