STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPIND1Heparin cofactor 2 isoform A; Belongs to the serpin family. (499 aa)    
Predicted Functional Partners:
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.923
FGB
Fibrinogen beta chain.
   
 0.846
FGG
Fibrinogen gamma chain.
   
 0.822
F13B
Coagulation factor XIII B chain.
   
 
 0.815
FGA
Fibrinogen alpha chain.
   
 0.813
SERPINC1
Antithrombin-III; Belongs to the serpin family.
  
 
0.786
SNAP29
Synaptosomal-associated protein 29.
      
 0.683
PI4KA
Phosphatidylinositol 4-kinase alpha isoform A; Belongs to the PI3/PI4-kinase family.
      
 0.658
VTN
Vitronectin.
   
 0.651
THBD
Thrombomodulin isoform A.
     
 0.607
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.