STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (541 aa)    
Predicted Functional Partners:
UBA3
NEDD8-activating enzyme E1 catalytic subunit isoform A.
   
0.999
NEDD8
NEDD8.
   
 0.981
UBE2M
NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.977
UBE2F
NEDD8-conjugating enzyme UBE2F; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.943
TRIP12
E3 ubiquitin-protein ligase TRIP12 isoform B.
    
 0.848
CUL1
Cullin-1; Belongs to the cullin family.
   
 0.846
RBX1
E3 ubiquitin-protein ligase RBX1.
   
 
 0.817
CUL3
Cullin-3; Belongs to the cullin family.
   
 0.793
ATG12
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.
    
 0.782
ATG3
Autophagy-related protein 3.
    
 0.776
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.