STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRF8Interferon regulatory factor 8 isoform B. (397 aa)    
Predicted Functional Partners:
STAT1
Signal transducer and activator of transcription.
   
 0.714
SPIB
Transcription factor Spi-B.
   
 
 0.606
IRF1
Interferon regulatory factor 1 isoform A.
   
0.569
MYD88
Myeloid differentiation primary response protein MyD88.
   
 0.567
KIT
Mast/stem cell growth factor receptor Kit isoform B; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 
 0.481
SPI1
Transcription factor PU.1.
   
 
 0.478
IFIH1
Interferon-induced helicase C domain-containing protein 1.
   
 0.466
BTLA
B-and T-lymphocyte attenuator.
   
  
 0.417
ZBTB46
Zinc finger and BTB domain-containing protein 46.
    
 0.411
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.