STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Y1Q_0006235Histone H2A; Belongs to the histone H2A family. (210 aa)    
Predicted Functional Partners:
MYSM1
Histone H2A deubiquitinase MYSM1 isoform B.
    
 0.966
Y1Q_0009388
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  
 0.733
KDM6B-2
Uncharacterized protein.
    
 0.721
KDM6B
Lysine-specific demethylase 6B isoform A.
    
 0.721
Y1Q_0020098
Histone H2B; Belongs to the histone H2B family.
 
 0.701
HIST2H2BE
Histone H2B; Belongs to the histone H2B family.
 
 0.701
HIST1H2BF
Histone H2B; Belongs to the histone H2B family.
 
 0.701
HIST1H2B5L
Histone H2B; Belongs to the histone H2B family.
 
 0.701
Y1Q_0012805
Histone H2B; Belongs to the histone H2B family.
 
 0.699
Y1Q_0020100
Histone H2B; Belongs to the histone H2B family.
 
 0.694
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.