STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (441 aa)    
Predicted Functional Partners:
PLCE1
Phosphoinositide phospholipase C.
   
 
 0.985
INPP5J
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform A.
   
 
 0.981
INPP5K
Inositol polyphosphate 5-phosphatase K isoform B.
   
 
 0.946
ITPKA
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.945
ITPKB
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.945
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
 0.919
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
 0.919
Y1Q_0014732
Phosphoinositide phospholipase C.
     
 0.919
INPP1
Inositol polyphosphate 1-phosphatase.
     
  0.913
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 
 0.910
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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