RND2 protein (Alligator mississippiensis) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

RND2

Rho-related GTP-binding protein RhoN. (227 aa)

Predicted Functional Partners:

ITSN1

0.989

ITSN1-2

0.923

ARHGAP35

0.788

MYO9B

0.766

MYO9B-2

0.766

TNFAIP1

0.738

KCTD13

0.735

KCTD10

0.733

Y1Q_0008971

0.723

DOCK4

0.709

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	RND2	A0A151P478	A0A151PC09	Rho GTPase-activating protein 35.	Rho-related GTP-binding protein RhoN.	0.788
DOCK4	RND2	A0A151PET4	A0A151PC09	Uncharacterized protein; Belongs to the DOCK family.	Rho-related GTP-binding protein RhoN.	0.709
ITSN1	ITSN1-2	A0A151PII8	A0A151ME63	Intersectin-1.	Uncharacterized protein.	0.944
ITSN1	RND2	A0A151PII8	A0A151PC09	Intersectin-1.	Rho-related GTP-binding protein RhoN.	0.989
ITSN1-2	ITSN1	A0A151ME63	A0A151PII8	Uncharacterized protein.	Intersectin-1.	0.944
ITSN1-2	RND2	A0A151ME63	A0A151PC09	Uncharacterized protein.	Rho-related GTP-binding protein RhoN.	0.923
KCTD10	KCTD13	A0A151NS12	A0A151NXA5	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	0.743
KCTD10	RND2	A0A151NS12	A0A151PC09	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	Rho-related GTP-binding protein RhoN.	0.733
KCTD10	TNFAIP1	A0A151NS12	A0A151N5S8	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.745
KCTD10	Y1Q_0008971	A0A151NS12	A0A151NKF4	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	Uncharacterized protein.	0.577
KCTD13	KCTD10	A0A151NXA5	A0A151NS12	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	0.743
KCTD13	RND2	A0A151NXA5	A0A151PC09	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	Rho-related GTP-binding protein RhoN.	0.735
KCTD13	TNFAIP1	A0A151NXA5	A0A151N5S8	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.753
MYO9B	RND2	A0A151ML75	A0A151PC09	Unconventional myosin-IXb isoform B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Rho-related GTP-binding protein RhoN.	0.766
MYO9B-2	RND2	A0A151NYC8	A0A151PC09	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Rho-related GTP-binding protein RhoN.	0.766
RND2	ARHGAP35	A0A151PC09	A0A151P478	Rho-related GTP-binding protein RhoN.	Rho GTPase-activating protein 35.	0.788
RND2	DOCK4	A0A151PC09	A0A151PET4	Rho-related GTP-binding protein RhoN.	Uncharacterized protein; Belongs to the DOCK family.	0.709
RND2	ITSN1	A0A151PC09	A0A151PII8	Rho-related GTP-binding protein RhoN.	Intersectin-1.	0.989
RND2	ITSN1-2	A0A151PC09	A0A151ME63	Rho-related GTP-binding protein RhoN.	Uncharacterized protein.	0.923
RND2	KCTD10	A0A151PC09	A0A151NS12	Rho-related GTP-binding protein RhoN.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	0.733

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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