STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
N302_12503E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (242 aa)    
Predicted Functional Partners:
N302_11221
Calcyclin-binding protein.
    
 0.937
N302_16051
Catenin beta-1.
    
 0.852
N302_03711
F-box-like/WD repeat-containing protein TBL1XR1.
    
 0.778
N302_13345
Ubiquitin-conjugating enzyme E2 variant 2.
    
   0.762
N302_09035
Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.739
N302_12593
Ubiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.739
N302_07148
Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.739
N302_06128
Alpha-synuclein; Belongs to the synuclein family.
    
 0.727
N302_08181
Junction plakoglobin.
    
 0.716
N302_03721
Ubiquitin carboxyl-terminal hydrolase.
    
 0.666
Your Current Organism:
Corvus brachyrhynchos
NCBI taxonomy Id: 85066
Other names: American crow, C. brachyrhynchos
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.