STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
N302_15408SET and MYND domain-containing protein 5. (383 aa)    
Predicted Functional Partners:
N302_03807
Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
    
 0.796
N302_10796
Polycomb protein EED.
    
 0.773
N302_03445
Set1/Ash2 histone methyltransferase complex subunit ASH2.
    
 0.771
N302_14780
Retinoblastoma-binding protein 5.
    
 0.771
N302_10299
Polycomb protein SUZ12.
    
 0.761
N302_02399
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
    
 0.757
N302_06340
Histone-lysine N-methyltransferase 2E.
    
 0.741
N302_12804
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.728
N302_09137
Lysine-specific demethylase 6A.
   
 0.724
N302_12647
PR domain zinc finger protein 4.
   
 0.724
Your Current Organism:
Corvus brachyrhynchos
NCBI taxonomy Id: 85066
Other names: American crow, C. brachyrhynchos
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.