STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN11Protein tyrosine phosphatase non-receptor type 11. (588 aa)    
Predicted Functional Partners:
GAB1
GRB2 associated binding protein 1.
    
 0.999
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.989
GRB2
Growth factor receptor bound protein 2.
   
 0.988
GAB2
GRB2 associated binding protein 2.
    
 0.970
PDGFRB
Platelet derived growth factor receptor beta.
   
 0.967
JAK2
Janus kinase 2.
   
 0.961
ENSSPUP00000002431
annotation not available
    
 0.958
FRS2
Fibroblast growth factor receptor substrate 2.
    
 0.956
SYK
Spleen associated tyrosine kinase.
   
 0.952
PECAM1
Platelet and endothelial cell adhesion molecule 1.
   
 0.949
Your Current Organism:
Sphenodon punctatus
NCBI taxonomy Id: 8508
Other names: Hatteria punctata, S. punctatus, hatteria, tuatara
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.