guaA_1 protein (Streptomyces turgidiscabies)

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Score

guaA_1

GMP synthase [glutamine-hydrolyzing]. (247 aa)

Predicted Functional Partners:

guaB_5

0.990

guaB_6

0.971

T45_07369

0.954

apt_2

0.927

hpt

0.919

guaB_4

0.918

gmk

0.917

guaA_2

0.912

rdgB

0.897

yhcR

0.893

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_07369	apt_2	T45_07369	T45_08408	Putative oxidoreductase/MSMEI_1564.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.478
T45_07369	gmk	T45_07369	T45_08440	Putative oxidoreductase/MSMEI_1564.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.671
T45_07369	guaA_1	T45_07369	T45_00203	Putative oxidoreductase/MSMEI_1564.	GMP synthase [glutamine-hydrolyzing].	0.954
T45_07369	guaA_2	T45_07369	T45_07354	Putative oxidoreductase/MSMEI_1564.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.998
T45_07369	guaB_4	T45_07369	T45_06939	Putative oxidoreductase/MSMEI_1564.	Inosine-5'-monophosphate dehydrogenase.	0.797
T45_07369	guaB_5	T45_07369	T45_07370	Putative oxidoreductase/MSMEI_1564.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.981
T45_07369	guaB_6	T45_07369	T45_08195	Putative oxidoreductase/MSMEI_1564.	Inosine-5'-monophosphate dehydrogenase.	0.891
T45_07369	hpt	T45_07369	T45_07524	Putative oxidoreductase/MSMEI_1564.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.910
T45_07369	rdgB	T45_07369	T45_04305	Putative oxidoreductase/MSMEI_1564.	DITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.912
T45_07369	yhcR	T45_07369	T45_05991	Putative oxidoreductase/MSMEI_1564.	Endonuclease YhcR precursor; Belongs to the 5'-nucleotidase family.	0.893
apt_2	T45_07369	T45_08408	T45_07369	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Putative oxidoreductase/MSMEI_1564.	0.478
apt_2	gmk	T45_08408	T45_08440	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.969
apt_2	guaA_1	T45_08408	T45_00203	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase [glutamine-hydrolyzing].	0.927
apt_2	guaA_2	T45_08408	T45_07354	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.994
apt_2	guaB_4	T45_08408	T45_06939	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase.	0.847
apt_2	guaB_5	T45_08408	T45_07370	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.901
apt_2	guaB_6	T45_08408	T45_08195	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase.	0.859
apt_2	hpt	T45_08408	T45_07524	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.952
apt_2	rdgB	T45_08408	T45_04305	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	DITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.474
apt_2	yhcR	T45_08408	T45_05991	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Endonuclease YhcR precursor; Belongs to the 5'-nucleotidase family.	0.909