glnB_1 protein (Streptomyces turgidiscabies)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

glnB_1

Nitrogen regulatory protein P-II. (112 aa)

Predicted Functional Partners:

nrgA

0.998

amt

0.988

glnD

0.985

argB

0.857

glnB_2

0.850

gltB_1

0.835

glnA_5

0.799

era

0.723

barA_2

0.705

glnII

0.682

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
amt	barA_2	T45_05787	T45_05328	Ammonia channel precursor.	Signal transduction histidine-protein kinase.	0.669
amt	glnA_5	T45_05787	T45_08810	Ammonia channel precursor.	Glutamine synthetase.	0.539
amt	glnB_1	T45_05787	T45_00507	Ammonia channel precursor.	Nitrogen regulatory protein P-II.	0.988
amt	glnB_2	T45_05787	T45_05786	Ammonia channel precursor.	Nitrogen regulatory protein P-II.	0.998
amt	glnD	T45_05787	T45_05785	Ammonia channel precursor.	Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.936
amt	glnII	T45_05787	T45_08784	Ammonia channel precursor.	Glutamine synthetase 2.	0.568
amt	gltB_1	T45_05787	T45_04042	Ammonia channel precursor.	Glutamate synthase [NADPH] large chain.	0.922
argB	glnB_1	T45_03307	T45_00507	Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.	Nitrogen regulatory protein P-II.	0.857
argB	glnB_2	T45_03307	T45_05786	Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.	Nitrogen regulatory protein P-II.	0.857
argB	gltB_1	T45_03307	T45_04042	Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.	Glutamate synthase [NADPH] large chain.	0.818
barA_2	amt	T45_05328	T45_05787	Signal transduction histidine-protein kinase.	Ammonia channel precursor.	0.669
barA_2	glnA_5	T45_05328	T45_08810	Signal transduction histidine-protein kinase.	Glutamine synthetase.	0.652
barA_2	glnB_1	T45_05328	T45_00507	Signal transduction histidine-protein kinase.	Nitrogen regulatory protein P-II.	0.705
barA_2	glnB_2	T45_05328	T45_05786	Signal transduction histidine-protein kinase.	Nitrogen regulatory protein P-II.	0.705
barA_2	glnD	T45_05328	T45_05785	Signal transduction histidine-protein kinase.	Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.592
barA_2	glnII	T45_05328	T45_08784	Signal transduction histidine-protein kinase.	Glutamine synthetase 2.	0.652
barA_2	gltB_1	T45_05328	T45_04042	Signal transduction histidine-protein kinase.	Glutamate synthase [NADPH] large chain.	0.939
barA_2	nrgA	T45_05328	T45_00506	Signal transduction histidine-protein kinase.	Ammonium transporter NrgA.	0.669
era	glnB_1	T45_00505	T45_00507	GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Nitrogen regulatory protein P-II.	0.723
era	nrgA	T45_00505	T45_00506	GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Ammonium transporter NrgA.	0.723