fgs protein (Streptomyces turgidiscabies) - STRING interaction network

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Score

fgs

Folylpolyglutamate synthase. (494 aa)

Predicted Functional Partners:

folP2

0.993

folP1

0.989

folP

0.986

dfrA

0.977

thyA2

0.961

T45_00601

0.943

folB

0.921

valS

0.890

folK

0.880

ndkA

0.843

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_00601	fgs	T45_00601	T45_00602	Hypothetical protein.	Folylpolyglutamate synthase.	0.943
T45_00601	ndkA	T45_00601	T45_00600	Hypothetical protein.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.829
T45_00601	valS	T45_00601	T45_00603	Hypothetical protein.	valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.	0.829
dfrA	fgs	T45_00970	T45_00602	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Folylpolyglutamate synthase.	0.977
dfrA	folP	T45_00970	T45_05110	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Dihydropteroate synthase.	0.535
dfrA	folP1	T45_00970	T45_07531	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Dihydropteroate synthase 1.	0.535
dfrA	folP2	T45_00970	T45_01773	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Inactive dihydropteroate synthase 2; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.606
dfrA	thyA2	T45_00970	T45_00969	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Thymidylate synthase 2.	0.999
fgs	T45_00601	T45_00602	T45_00601	Folylpolyglutamate synthase.	Hypothetical protein.	0.943
fgs	dfrA	T45_00602	T45_00970	Folylpolyglutamate synthase.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.977
fgs	folB	T45_00602	T45_07529	Folylpolyglutamate synthase.	Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.921
fgs	folK	T45_00602	T45_07528	Folylpolyglutamate synthase.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.880
fgs	folP	T45_00602	T45_05110	Folylpolyglutamate synthase.	Dihydropteroate synthase.	0.986
fgs	folP1	T45_00602	T45_07531	Folylpolyglutamate synthase.	Dihydropteroate synthase 1.	0.989
fgs	folP2	T45_00602	T45_01773	Folylpolyglutamate synthase.	Inactive dihydropteroate synthase 2; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.993
fgs	ndkA	T45_00602	T45_00600	Folylpolyglutamate synthase.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.843
fgs	thyA2	T45_00602	T45_00969	Folylpolyglutamate synthase.	Thymidylate synthase 2.	0.961
fgs	valS	T45_00602	T45_00603	Folylpolyglutamate synthase.	valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.	0.890
folB	fgs	T45_07529	T45_00602	Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Folylpolyglutamate synthase.	0.921
folB	folK	T45_07529	T45_07528	Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.999