T45_00733 protein (Streptomyces turgidiscabies)

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Score

T45_00733

Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family. (281 aa)

Predicted Functional Partners:

metH

0.997

T45_05896

0.962

gcvT_3

0.927

glyA_1

0.874

glyA_2

0.874

glyA2

0.874

thyX

0.854

folD_1

0.852

thyA2

0.851

mlr_1

0.848

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_00733	T45_05896	T45_00733	T45_05896	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Cobalamin-independent synthase, Catalytic.	0.962
T45_00733	folD_1	T45_00733	T45_01446	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.852
T45_00733	gcvT_3	T45_00733	T45_05936	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.927
T45_00733	glyA2	T45_00733	T45_05938	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.874
T45_00733	glyA_1	T45_00733	T45_01469	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.874
T45_00733	glyA_2	T45_00733	T45_02021	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.874
T45_00733	metH	T45_00733	T45_03400	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.997
T45_00733	mlr_1	T45_00733	T45_00712	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	4-methylaminobutanoate oxidase; Belongs to the GcvT family.	0.848
T45_00733	thyA2	T45_00733	T45_00969	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Thymidylate synthase 2.	0.851
T45_00733	thyX	T45_00733	T45_08112	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.854
T45_05896	T45_00733	T45_05896	T45_00733	Cobalamin-independent synthase, Catalytic.	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	0.962
T45_05896	gcvT_3	T45_05896	T45_05936	Cobalamin-independent synthase, Catalytic.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.523
T45_05896	metH	T45_05896	T45_03400	Cobalamin-independent synthase, Catalytic.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.986
folD_1	T45_00733	T45_01446	T45_00733	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.	0.852
folD_1	gcvT_3	T45_01446	T45_05936	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.963
folD_1	glyA2	T45_01446	T45_05938	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.968
folD_1	glyA_1	T45_01446	T45_01469	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.968
folD_1	glyA_2	T45_01446	T45_02021	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.967
folD_1	metH	T45_01446	T45_03400	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.715
folD_1	mlr_1	T45_01446	T45_00712	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	4-methylaminobutanoate oxidase; Belongs to the GcvT family.	0.896