T45_00775 protein (Streptomyces turgidiscabies)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

T45_00775

Serine protease. (399 aa)

Predicted Functional Partners:

T45_00776

0.951

ftsH_1

0.894

arc

0.894

glpK_1

0.798

glpK_2

0.798

glpK_3

0.798

pdg

0.794

mec

0.754

wapA_7

0.754

T45_08247

0.754

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_00775	T45_00776	T45_00775	T45_00776	Serine protease.	Putative NUDIX hydrolase.	0.951
T45_00775	T45_08247	T45_00775	T45_08247	Serine protease.	Hypothetical protein.	0.754
T45_00775	arc	T45_00775	T45_03386	Serine protease.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.894
T45_00775	ftsH_1	T45_00775	T45_01398	Serine protease.	ATP-dependent zinc metalloprotease FtsH; Belongs to the AAA ATPase family.	0.894
T45_00775	glpK_1	T45_00775	T45_03403	Serine protease.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.798
T45_00775	glpK_2	T45_00775	T45_08126	Serine protease.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.798
T45_00775	glpK_3	T45_00775	T45_08448	Serine protease.	Glycerol kinase; Belongs to the FGGY kinase family.	0.798
T45_00775	mec	T45_00775	T45_04314	Serine protease.	cysO-cysteine peptidase.	0.754
T45_00775	pdg	T45_00775	T45_00777	Serine protease.	Ultraviolet N-glycosylase/AP lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.794
T45_00775	wapA_7	T45_00775	T45_04491	Serine protease.	tRNA nuclease WapA precursor.	0.754
T45_00776	T45_00775	T45_00776	T45_00775	Putative NUDIX hydrolase.	Serine protease.	0.951
T45_00776	pdg	T45_00776	T45_00777	Putative NUDIX hydrolase.	Ultraviolet N-glycosylase/AP lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.784
T45_08247	T45_00775	T45_08247	T45_00775	Hypothetical protein.	Serine protease.	0.754
T45_08247	arc	T45_08247	T45_03386	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.991
T45_08247	ftsH_1	T45_08247	T45_01398	Hypothetical protein.	ATP-dependent zinc metalloprotease FtsH; Belongs to the AAA ATPase family.	0.991
T45_08247	glpK_1	T45_08247	T45_03403	Hypothetical protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.973
T45_08247	glpK_2	T45_08247	T45_08126	Hypothetical protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.973
T45_08247	glpK_3	T45_08247	T45_08448	Hypothetical protein.	Glycerol kinase; Belongs to the FGGY kinase family.	0.973
arc	T45_00775	T45_03386	T45_00775	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Serine protease.	0.894
arc	T45_08247	T45_03386	T45_08247	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Hypothetical protein.	0.991