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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
T45_01712Hypothetical protein. (448 aa)    
Predicted Functional Partners:
T45_01711
CobQ/CobB/MinD/ParA nucleotide binding domain.
       0.791
T45_01710
Hypothetical protein.
       0.577
T45_01709
Hypothetical protein.
       0.564
gyrBR
DNA gyrase subunit B, novobiocin-resistant; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-de [...]
    
 
 0.539
T45_04660
Hypothetical protein.
    
 
 0.539
gyrB
DNA gyrase subunit B.
    
 
 0.539
T45_01713
Hypothetical protein.
       0.531
yokD_2
SPBc2 prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD.
       0.506
embR_1
Transcriptional regulatory protein EmbR.
    
  0.480
embR_2
Transcriptional regulatory protein EmbR.
    
  0.480
Your Current Organism:
Streptomyces turgidiscabies
NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113
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