htrA_2 protein (Streptomyces turgidiscabies)

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Score

htrA_2

Serine protease Do-like HtrA. (547 aa)

Predicted Functional Partners:

ftsH_1

0.894

arc

0.894

degP

0.868

glpK_1

0.798

glpK_2

0.798

glpK_3

0.798

mec

0.754

wapA_7

0.754

T45_08247

0.754

secD_2

0.709

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_08247	arc	T45_08247	T45_03386	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.991
T45_08247	degP	T45_08247	T45_06001	Hypothetical protein.	Periplasmic serine endoprotease DegP precursor.	0.754
T45_08247	ftsH_1	T45_08247	T45_01398	Hypothetical protein.	ATP-dependent zinc metalloprotease FtsH; Belongs to the AAA ATPase family.	0.991
T45_08247	glpK_1	T45_08247	T45_03403	Hypothetical protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.973
T45_08247	glpK_2	T45_08247	T45_08126	Hypothetical protein.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.973
T45_08247	glpK_3	T45_08247	T45_08448	Hypothetical protein.	Glycerol kinase; Belongs to the FGGY kinase family.	0.973
T45_08247	htrA_2	T45_08247	T45_01781	Hypothetical protein.	Serine protease Do-like HtrA.	0.754
arc	T45_08247	T45_03386	T45_08247	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Hypothetical protein.	0.991
arc	degP	T45_03386	T45_06001	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Periplasmic serine endoprotease DegP precursor.	0.894
arc	glpK_1	T45_03386	T45_03403	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.989
arc	glpK_2	T45_03386	T45_08126	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.989
arc	glpK_3	T45_03386	T45_08448	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Glycerol kinase; Belongs to the FGGY kinase family.	0.989
arc	htrA_2	T45_03386	T45_01781	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	Serine protease Do-like HtrA.	0.894
arc	mec	T45_03386	T45_04314	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	cysO-cysteine peptidase.	0.991
arc	wapA_7	T45_03386	T45_04491	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	tRNA nuclease WapA precursor.	0.991
degP	T45_08247	T45_06001	T45_08247	Periplasmic serine endoprotease DegP precursor.	Hypothetical protein.	0.754
degP	arc	T45_06001	T45_03386	Periplasmic serine endoprotease DegP precursor.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.894
degP	ftsH_1	T45_06001	T45_01398	Periplasmic serine endoprotease DegP precursor.	ATP-dependent zinc metalloprotease FtsH; Belongs to the AAA ATPase family.	0.894
degP	glpK_1	T45_06001	T45_03403	Periplasmic serine endoprotease DegP precursor.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.798
degP	glpK_2	T45_06001	T45_08126	Periplasmic serine endoprotease DegP precursor.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.798