kgd protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

kgd

Multifunctional 2-oxoglutarate metabolism enzyme. (1265 aa)

Predicted Functional Partners:

sucD_1

0.999

sucC_1

0.999

sucD_2

0.999

sucC_2

0.999

acoA

0.998

pdhD

0.998

lpdC

0.998

lpdA

0.993

gltA2

0.993

T45_08491

0.993

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_08491	acoA	T45_08491	T45_02982	NADH oxidase.	Acetoin:2,6-dichlorophenolindophenol.	0.974
T45_08491	gltA2	T45_08491	T45_07891	NADH oxidase.	Citrate synthase 1; Belongs to the citrate synthase family.	0.622
T45_08491	kgd	T45_08491	T45_01930	NADH oxidase.	Multifunctional 2-oxoglutarate metabolism enzyme.	0.993
T45_08491	sucC_1	T45_08491	T45_07330	NADH oxidase.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.662
T45_08491	sucC_2	T45_08491	T45_09339	NADH oxidase.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.662
T45_08491	sucD_1	T45_08491	T45_07329	NADH oxidase.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.715
T45_08491	sucD_2	T45_08491	T45_09338	NADH oxidase.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.715
acoA	T45_08491	T45_02982	T45_08491	Acetoin:2,6-dichlorophenolindophenol.	NADH oxidase.	0.974
acoA	gltA2	T45_02982	T45_07891	Acetoin:2,6-dichlorophenolindophenol.	Citrate synthase 1; Belongs to the citrate synthase family.	0.631
acoA	kgd	T45_02982	T45_01930	Acetoin:2,6-dichlorophenolindophenol.	Multifunctional 2-oxoglutarate metabolism enzyme.	0.998
acoA	lpdA	T45_02982	T45_01563	Acetoin:2,6-dichlorophenolindophenol.	NAD(P)H dehydrogenase.	0.985
acoA	lpdC	T45_02982	T45_05690	Acetoin:2,6-dichlorophenolindophenol.	Dihydrolipoyl dehydrogenase.	0.984
acoA	pdhD	T45_02982	T45_03890	Acetoin:2,6-dichlorophenolindophenol.	Dihydrolipoyl dehydrogenase.	0.987
acoA	sucC_1	T45_02982	T45_07330	Acetoin:2,6-dichlorophenolindophenol.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.656
acoA	sucC_2	T45_02982	T45_09339	Acetoin:2,6-dichlorophenolindophenol.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.656
acoA	sucD_1	T45_02982	T45_07329	Acetoin:2,6-dichlorophenolindophenol.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.568
acoA	sucD_2	T45_02982	T45_09338	Acetoin:2,6-dichlorophenolindophenol.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.568
gltA2	T45_08491	T45_07891	T45_08491	Citrate synthase 1; Belongs to the citrate synthase family.	NADH oxidase.	0.622
gltA2	acoA	T45_07891	T45_02982	Citrate synthase 1; Belongs to the citrate synthase family.	Acetoin:2,6-dichlorophenolindophenol.	0.631
gltA2	kgd	T45_07891	T45_01930	Citrate synthase 1; Belongs to the citrate synthase family.	Multifunctional 2-oxoglutarate metabolism enzyme.	0.993