msrB protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

msrB

Peptide methionine sulfoxide reductase MsrB. (135 aa)

Predicted Functional Partners:

msrA3

0.995

grpE

0.798

murC_1

0.779

rpmJ

0.727

T45_02742

0.690

rplT

0.682

resA

0.668

trxA_5

0.668

rpsI

0.657

rplK

0.657

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_02742	msrB	T45_02742	T45_02740	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.690
T45_02742	murC_1	T45_02742	T45_02741	Hypothetical protein.	UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.	0.746
grpE	msrB	T45_00954	T45_02740	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	Peptide methionine sulfoxide reductase MsrB.	0.798
grpE	resA	T45_00954	T45_06675	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	Thiol-disulfide oxidoreductase ResA.	0.407
grpE	trxA_5	T45_00954	T45_06742	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	Thioredoxin.	0.407
msrA3	msrB	T45_01590	T45_02740	Peptide methionine sulfoxide reductase MsrA 3; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	Peptide methionine sulfoxide reductase MsrB.	0.995
msrA3	resA	T45_01590	T45_06675	Peptide methionine sulfoxide reductase MsrA 3; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	Thiol-disulfide oxidoreductase ResA.	0.910
msrA3	trxA_5	T45_01590	T45_06742	Peptide methionine sulfoxide reductase MsrA 3; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	Thioredoxin.	0.899
msrB	T45_02742	T45_02740	T45_02742	Peptide methionine sulfoxide reductase MsrB.	Hypothetical protein.	0.690
msrB	grpE	T45_02740	T45_00954	Peptide methionine sulfoxide reductase MsrB.	Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]	0.798
msrB	msrA3	T45_02740	T45_01590	Peptide methionine sulfoxide reductase MsrB.	Peptide methionine sulfoxide reductase MsrA 3; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	0.995
msrB	murC_1	T45_02740	T45_02741	Peptide methionine sulfoxide reductase MsrB.	UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.	0.779
msrB	resA	T45_02740	T45_06675	Peptide methionine sulfoxide reductase MsrB.	Thiol-disulfide oxidoreductase ResA.	0.668
msrB	rplK	T45_02740	T45_07184	Peptide methionine sulfoxide reductase MsrB.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.657
msrB	rplT	T45_02740	T45_03333	Peptide methionine sulfoxide reductase MsrB.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.682
msrB	rpmJ	T45_02740	T45_04386	Peptide methionine sulfoxide reductase MsrB.	50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	0.727
msrB	rpsI	T45_02740	T45_04378	Peptide methionine sulfoxide reductase MsrB.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.657
msrB	trxA_5	T45_02740	T45_06742	Peptide methionine sulfoxide reductase MsrB.	Thioredoxin.	0.668
murC_1	T45_02742	T45_02741	T45_02742	UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.	Hypothetical protein.	0.746
murC_1	msrB	T45_02741	T45_02740	UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.	Peptide methionine sulfoxide reductase MsrB.	0.779