lmrA protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

lmrA

Multidrug resistance ABC transporter ATP-binding and permease protein. (238 aa)

Predicted Functional Partners:

dnaK_1

0.801

dnaK_2

0.798

ftsH_1

0.749

dnaJ_1

0.681

pks2

0.663

ppsE_1

0.653

cydD

0.652

irtA

0.652

dhbF_8

0.644

acuC

0.640

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acuC	dhbF_8	T45_06550	T45_05484	Acetoin utilization protein AcuC.	Dimodular nonribosomal peptide synthase.	0.514
acuC	dnaJ_1	T45_06550	T45_00531	Acetoin utilization protein AcuC.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.663
acuC	dnaK_1	T45_06550	T45_00955	Acetoin utilization protein AcuC.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.772
acuC	dnaK_2	T45_06550	T45_04847	Acetoin utilization protein AcuC.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.772
acuC	lmrA	T45_06550	T45_03200	Acetoin utilization protein AcuC.	Multidrug resistance ABC transporter ATP-binding and permease protein.	0.640
acuC	pks2	T45_06550	T45_01967	Acetoin utilization protein AcuC.	Phthioceranic/hydroxyphthioceranic acid.	0.413
cydD	lmrA	T45_01347	T45_03200	ATP-binding/permease protein CydD.	Multidrug resistance ABC transporter ATP-binding and permease protein.	0.652
dhbF_8	acuC	T45_05484	T45_06550	Dimodular nonribosomal peptide synthase.	Acetoin utilization protein AcuC.	0.514
dhbF_8	dnaJ_1	T45_05484	T45_00531	Dimodular nonribosomal peptide synthase.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.741
dhbF_8	dnaK_1	T45_05484	T45_00955	Dimodular nonribosomal peptide synthase.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.763
dhbF_8	dnaK_2	T45_05484	T45_04847	Dimodular nonribosomal peptide synthase.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.763
dhbF_8	irtA	T45_05484	T45_09114	Dimodular nonribosomal peptide synthase.	Iron import ATP-binding/permease protein IrtA.	0.742
dhbF_8	lmrA	T45_05484	T45_03200	Dimodular nonribosomal peptide synthase.	Multidrug resistance ABC transporter ATP-binding and permease protein.	0.644
dhbF_8	pks2	T45_05484	T45_01967	Dimodular nonribosomal peptide synthase.	Phthioceranic/hydroxyphthioceranic acid.	0.999
dhbF_8	ppsE_1	T45_05484	T45_02351	Dimodular nonribosomal peptide synthase.	Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE.	0.999
dnaJ_1	acuC	T45_00531	T45_06550	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Acetoin utilization protein AcuC.	0.663
dnaJ_1	dhbF_8	T45_00531	T45_05484	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Dimodular nonribosomal peptide synthase.	0.741
dnaJ_1	dnaK_1	T45_00531	T45_00955	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.992
dnaJ_1	dnaK_2	T45_00531	T45_04847	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.992
dnaJ_1	ftsH_1	T45_00531	T45_01398	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	ATP-dependent zinc metalloprotease FtsH; Belongs to the AAA ATPase family.	0.685