node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T45_01231 | arc | T45_01231 | T45_03386 | Hypothetical protein. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.808 |
T45_01231 | dop | T45_01231 | T45_03385 | Hypothetical protein. | Depupylase. | 0.679 |
T45_01231 | pafA | T45_01231 | T45_03378 | Hypothetical protein. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.745 |
T45_01231 | prcA | T45_01231 | T45_03381 | Hypothetical protein. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.999 |
T45_01231 | prcB | T45_01231 | T45_03382 | Hypothetical protein. | Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.992 |
T45_01231 | pup | T45_01231 | T45_03384 | Hypothetical protein. | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.766 |
T45_03383 | arc | T45_03383 | T45_03386 | Recombination endonuclease VII. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.626 |
T45_03383 | dop | T45_03383 | T45_03385 | Recombination endonuclease VII. | Depupylase. | 0.667 |
T45_03383 | prcA | T45_03383 | T45_03381 | Recombination endonuclease VII. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.781 |
T45_03383 | prcB | T45_03383 | T45_03382 | Recombination endonuclease VII. | Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.884 |
T45_03383 | pup | T45_03383 | T45_03384 | Recombination endonuclease VII. | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.734 |
T45_03387 | arc | T45_03387 | T45_03386 | Hypothetical protein. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.779 |
T45_03387 | dop | T45_03387 | T45_03385 | Hypothetical protein. | Depupylase. | 0.731 |
T45_03387 | prcA | T45_03387 | T45_03381 | Hypothetical protein. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.669 |
T45_03387 | prcB | T45_03387 | T45_03382 | Hypothetical protein. | Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.678 |
T45_03387 | pup | T45_03387 | T45_03384 | Hypothetical protein. | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.720 |
T45_03938 | arc | T45_03938 | T45_03386 | Polyketide cyclase / dehydrase and lipid transport. | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.404 |
T45_03938 | dop | T45_03938 | T45_03385 | Polyketide cyclase / dehydrase and lipid transport. | Depupylase. | 0.409 |
T45_03938 | pup | T45_03938 | T45_03384 | Polyketide cyclase / dehydrase and lipid transport. | Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.559 |
arc | T45_01231 | T45_03386 | T45_01231 | Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Hypothetical protein. | 0.808 |