hmgA protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

hmgA

Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (452 aa)

Predicted Functional Partners:

hpd

0.997

T45_02355

0.990

fahA

0.986

lly

0.986

mce

0.885

T45_09059

0.874

yvoA_6

0.843

T45_03515

0.807

tetR_3

0.778

citN

0.697

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_02355	fahA	T45_02355	T45_07240	4-hydroxymandelate synthase.	Fumarylacetoacetate (FAA hydrolase family.	0.889
T45_02355	hmgA	T45_02355	T45_03513	4-hydroxymandelate synthase.	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	0.990
T45_02355	lly	T45_02355	T45_08832	4-hydroxymandelate synthase.	4-hydroxyphenylpyruvate dioxygenase.	0.803
T45_03515	citN	T45_03515	T45_03510	Hypothetical protein.	Citrate transporter.	0.679
T45_03515	hmgA	T45_03515	T45_03513	Hypothetical protein.	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	0.807
T45_03515	tetR_3	T45_03515	T45_03512	Hypothetical protein.	Tetracycline repressor protein class G.	0.729
T45_03515	yvoA_6	T45_03515	T45_03514	Hypothetical protein.	HTH-type transcriptional repressor YvoA.	0.843
T45_09059	hmgA	T45_09059	T45_03513	Hypothetical protein.	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	0.874
citN	T45_03515	T45_03510	T45_03515	Citrate transporter.	Hypothetical protein.	0.679
citN	hmgA	T45_03510	T45_03513	Citrate transporter.	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	0.697
citN	tetR_3	T45_03510	T45_03512	Citrate transporter.	Tetracycline repressor protein class G.	0.687
citN	yvoA_6	T45_03510	T45_03514	Citrate transporter.	HTH-type transcriptional repressor YvoA.	0.644
fahA	T45_02355	T45_07240	T45_02355	Fumarylacetoacetate (FAA hydrolase family.	4-hydroxymandelate synthase.	0.889
fahA	hmgA	T45_07240	T45_03513	Fumarylacetoacetate (FAA hydrolase family.	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	0.986
fahA	hpd	T45_07240	T45_04328	Fumarylacetoacetate (FAA hydrolase family.	4-hydroxyphenylpyruvate dioxygenase.	0.951
fahA	lly	T45_07240	T45_08832	Fumarylacetoacetate (FAA hydrolase family.	4-hydroxyphenylpyruvate dioxygenase.	0.411
hmgA	T45_02355	T45_03513	T45_02355	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	4-hydroxymandelate synthase.	0.990
hmgA	T45_03515	T45_03513	T45_03515	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	Hypothetical protein.	0.807
hmgA	T45_09059	T45_03513	T45_09059	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	Hypothetical protein.	0.874
hmgA	citN	T45_03513	T45_03510	Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.	Citrate transporter.	0.697

page 1 of 3

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About