frc_1 protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

frc_1

Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family. (396 aa)

Predicted Functional Partners:

sucC_1

0.780

sucC_2

0.780

sucD_1

0.680

sucD_2

0.680

korA

0.640

paaZ

0.570

scpA_1

0.567

accA

0.540

mutA

0.520

mutB_1

0.520

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
accA	frc_1	T45_00189	T45_03519	Acetyl-coenzyme A carboxylase carboxyl.	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	0.540
accA	korA	T45_00189	T45_07222	Acetyl-coenzyme A carboxylase carboxyl.	2-oxoglutarate oxidoreductase subunit KorA.	0.892
accA	mutA	T45_00189	T45_03650	Acetyl-coenzyme A carboxylase carboxyl.	methylmalonyl-CoA mutase small subunit.	0.581
accA	mutB_1	T45_00189	T45_03651	Acetyl-coenzyme A carboxylase carboxyl.	methylmalonyl-CoA mutase large subunit.	0.581
accA	paaZ	T45_00189	T45_04791	Acetyl-coenzyme A carboxylase carboxyl.	Bifunctional protein PaaZ.	0.736
accA	scpA_1	T45_00189	T45_00742	Acetyl-coenzyme A carboxylase carboxyl.	methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.	0.664
accA	sucC_1	T45_00189	T45_07330	Acetyl-coenzyme A carboxylase carboxyl.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.866
accA	sucC_2	T45_00189	T45_09339	Acetyl-coenzyme A carboxylase carboxyl.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.866
accA	sucD_1	T45_00189	T45_07329	Acetyl-coenzyme A carboxylase carboxyl.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.864
accA	sucD_2	T45_00189	T45_09338	Acetyl-coenzyme A carboxylase carboxyl.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.864
frc_1	accA	T45_03519	T45_00189	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	Acetyl-coenzyme A carboxylase carboxyl.	0.540
frc_1	korA	T45_03519	T45_07222	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	2-oxoglutarate oxidoreductase subunit KorA.	0.640
frc_1	mutA	T45_03519	T45_03650	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	methylmalonyl-CoA mutase small subunit.	0.520
frc_1	mutB_1	T45_03519	T45_03651	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	methylmalonyl-CoA mutase large subunit.	0.520
frc_1	paaZ	T45_03519	T45_04791	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	Bifunctional protein PaaZ.	0.570
frc_1	scpA_1	T45_03519	T45_00742	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.	0.567
frc_1	sucC_1	T45_03519	T45_07330	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.780
frc_1	sucC_2	T45_03519	T45_09339	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.780
frc_1	sucD_1	T45_03519	T45_07329	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.680
frc_1	sucD_2	T45_03519	T45_09338	Formyl-coenzyme A transferase; Belongs to the CoA-transferase III family.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.680