T45_04563 protein (Streptomyces turgidiscabies)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

T45_04563

Hypothetical protein. (141 aa)

Predicted Functional Partners:

apbE_3

0.932

fumA

0.785

adh_2

0.569

T45_01505

0.461

sdhC

0.461

fumC

0.461

ackA

0.461

hutU

0.461

T45_00049

0.419

sucD_1

0.417

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_00049	T45_04563	T45_00049	T45_04563	Transglycosylase SLT domain protein.	Hypothetical protein.	0.419
T45_01505	T45_04563	T45_01505	T45_04563	Succinate dehydrogenase cytochrome b556 small.	Hypothetical protein.	0.461
T45_01505	fumA	T45_01505	T45_01693	Succinate dehydrogenase cytochrome b556 small.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.988
T45_01505	fumC	T45_01505	T45_01692	Succinate dehydrogenase cytochrome b556 small.	Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.943
T45_01505	sdhC	T45_01505	T45_01506	Succinate dehydrogenase cytochrome b556 small.	Succinate dehydrogenase/Fumarate reductase.	0.999
T45_01505	sucD_1	T45_01505	T45_07329	Succinate dehydrogenase cytochrome b556 small.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.851
T45_04563	T45_00049	T45_04563	T45_00049	Hypothetical protein.	Transglycosylase SLT domain protein.	0.419
T45_04563	T45_01505	T45_04563	T45_01505	Hypothetical protein.	Succinate dehydrogenase cytochrome b556 small.	0.461
T45_04563	ackA	T45_04563	T45_02079	Hypothetical protein.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.461
T45_04563	adh_2	T45_04563	T45_04561	Hypothetical protein.	NADP-dependent isopropanol dehydrogenase.	0.569
T45_04563	apbE_3	T45_04563	T45_04562	Hypothetical protein.	Thiamine biosynthesis lipoprotein ApbE precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.	0.932
T45_04563	fumA	T45_04563	T45_01693	Hypothetical protein.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.785
T45_04563	fumC	T45_04563	T45_01692	Hypothetical protein.	Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.461
T45_04563	hutU	T45_04563	T45_08595	Hypothetical protein.	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.	0.461
T45_04563	sdhC	T45_04563	T45_01506	Hypothetical protein.	Succinate dehydrogenase/Fumarate reductase.	0.461
T45_04563	sucD_1	T45_04563	T45_07329	Hypothetical protein.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.417
ackA	T45_04563	T45_02079	T45_04563	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Hypothetical protein.	0.461
ackA	fumA	T45_02079	T45_01693	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.601
ackA	sucD_1	T45_02079	T45_07329	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.588
adh_2	T45_04563	T45_04561	T45_04563	NADP-dependent isopropanol dehydrogenase.	Hypothetical protein.	0.569