mcl1 protein (Streptomyces turgidiscabies) - STRING interaction network

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Score

mcl1

malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (321 aa)

Predicted Functional Partners:

paaZ

0.983

mutB_2

0.930

citE

0.921

ccrA2

0.918

mmgC_12

0.912

aceB

0.903

pta

0.897

accD5_1

0.894

acsA_1

0.890

fumA

0.885

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
accD5_1	aceB	T45_01571	T45_04707	Putative propionyl-CoA carboxylase beta chain 5.	Malate synthase; Belongs to the malate synthase family.	0.608
accD5_1	acsA_1	T45_01571	T45_00771	Putative propionyl-CoA carboxylase beta chain 5.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.905
accD5_1	citE	T45_01571	T45_04035	Putative propionyl-CoA carboxylase beta chain 5.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.504
accD5_1	fumA	T45_01571	T45_01693	Putative propionyl-CoA carboxylase beta chain 5.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.536
accD5_1	mcl1	T45_01571	T45_04792	Putative propionyl-CoA carboxylase beta chain 5.	malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family.	0.894
accD5_1	mutB_2	T45_01571	T45_04793	Putative propionyl-CoA carboxylase beta chain 5.	methylmalonyl-CoA mutase large subunit.	0.512
accD5_1	pta	T45_01571	T45_02080	Putative propionyl-CoA carboxylase beta chain 5.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.899
aceB	accD5_1	T45_04707	T45_01571	Malate synthase; Belongs to the malate synthase family.	Putative propionyl-CoA carboxylase beta chain 5.	0.608
aceB	acsA_1	T45_04707	T45_00771	Malate synthase; Belongs to the malate synthase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.950
aceB	citE	T45_04707	T45_04035	Malate synthase; Belongs to the malate synthase family.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.796
aceB	fumA	T45_04707	T45_01693	Malate synthase; Belongs to the malate synthase family.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.938
aceB	mcl1	T45_04707	T45_04792	Malate synthase; Belongs to the malate synthase family.	malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family.	0.903
aceB	mutB_2	T45_04707	T45_04793	Malate synthase; Belongs to the malate synthase family.	methylmalonyl-CoA mutase large subunit.	0.487
aceB	paaZ	T45_04707	T45_04791	Malate synthase; Belongs to the malate synthase family.	Bifunctional protein PaaZ.	0.519
aceB	pta	T45_04707	T45_02080	Malate synthase; Belongs to the malate synthase family.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.990
acsA_1	accD5_1	T45_00771	T45_01571	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Putative propionyl-CoA carboxylase beta chain 5.	0.905
acsA_1	aceB	T45_00771	T45_04707	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Malate synthase; Belongs to the malate synthase family.	0.950
acsA_1	ccrA2	T45_00771	T45_04794	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	crotonyl-CoA reductase.	0.456
acsA_1	citE	T45_00771	T45_04035	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Citrate lyase subunit beta; Belongs to the HpcH/HpaI aldolase family.	0.773
acsA_1	fumA	T45_00771	T45_01693	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.417