icd protein (Streptomyces turgidiscabies) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

icd

Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (739 aa)

Predicted Functional Partners:

korA

0.990

T45_01767

0.982

acnA

0.972

mdh

0.952

gltB_1

0.935

korB

0.919

kgd

0.917

purB

0.888

nadB_2

0.887

gdhA

0.876

Your Current Organism:

Streptomyces turgidiscabies

NCBI taxonomy Id: 85558
Other names: ATCC 700248, CIP 105577, IFO 16080, JCM 10429, NBRC 16080, NRRL B-24078, S. turgidiscabies, strain SY9113

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T45_01767	acnA	T45_01767	T45_02802	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.626
T45_01767	gdhA	T45_01767	T45_05576	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.856
T45_01767	gltB_1	T45_01767	T45_04042	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Glutamate synthase [NADPH] large chain.	0.970
T45_01767	icd	T45_01767	T45_04997	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family.	0.982
T45_01767	kgd	T45_01767	T45_01930	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Multifunctional 2-oxoglutarate metabolism enzyme.	0.923
T45_01767	korA	T45_01767	T45_07222	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	2-oxoglutarate oxidoreductase subunit KorA.	0.999
T45_01767	korB	T45_01767	T45_07223	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	2-oxoglutarate oxidoreductase subunit KorB.	0.979
T45_01767	mdh	T45_01767	T45_01450	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.990
T45_01767	nadB_2	T45_01767	T45_07545	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.876
T45_01767	purB	T45_01767	T45_03020	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.556
acnA	T45_01767	T45_02802	T45_01767	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.626
acnA	gdhA	T45_02802	T45_05576	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.526
acnA	gltB_1	T45_02802	T45_04042	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Glutamate synthase [NADPH] large chain.	0.723
acnA	icd	T45_02802	T45_04997	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family.	0.972
acnA	kgd	T45_02802	T45_01930	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Multifunctional 2-oxoglutarate metabolism enzyme.	0.982
acnA	korA	T45_02802	T45_07222	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	2-oxoglutarate oxidoreductase subunit KorA.	0.610
acnA	mdh	T45_02802	T45_01450	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.948
acnA	nadB_2	T45_02802	T45_07545	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.440
gdhA	T45_01767	T45_05576	T45_01767	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.856
gdhA	acnA	T45_05576	T45_02802	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.526