node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dat_2 | ilvB1 | T45_08372 | T45_05877 | D-alanine aminotransferase. | Acetolactate synthase large subunit IlvB1. | 0.591 |
dat_2 | ilvC | T45_08372 | T45_05875 | D-alanine aminotransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.445 |
dat_2 | ilvD | T45_08372 | T45_07572 | D-alanine aminotransferase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.975 |
dat_2 | ilvE | T45_08372 | T45_05863 | D-alanine aminotransferase. | Branched-chain-amino-acid aminotransferase. | 0.893 |
dat_2 | ilvH | T45_08372 | T45_05876 | D-alanine aminotransferase. | Acetolactate synthase small subunit. | 0.740 |
dat_2 | leuA_1 | T45_08372 | T45_00497 | D-alanine aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.963 |
dat_2 | leuA_2 | T45_08372 | T45_05856 | D-alanine aminotransferase. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.967 |
dat_2 | leuC | T45_08372 | T45_05822 | D-alanine aminotransferase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.477 |
ilvB1 | dat_2 | T45_05877 | T45_08372 | Acetolactate synthase large subunit IlvB1. | D-alanine aminotransferase. | 0.591 |
ilvB1 | ilvC | T45_05877 | T45_05875 | Acetolactate synthase large subunit IlvB1. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
ilvB1 | ilvD | T45_05877 | T45_07572 | Acetolactate synthase large subunit IlvB1. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.935 |
ilvB1 | ilvE | T45_05877 | T45_05863 | Acetolactate synthase large subunit IlvB1. | Branched-chain-amino-acid aminotransferase. | 0.749 |
ilvB1 | ilvH | T45_05877 | T45_05876 | Acetolactate synthase large subunit IlvB1. | Acetolactate synthase small subunit. | 0.999 |
ilvB1 | leuA_1 | T45_05877 | T45_00497 | Acetolactate synthase large subunit IlvB1. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.959 |
ilvB1 | leuA_2 | T45_05877 | T45_05856 | Acetolactate synthase large subunit IlvB1. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.952 |
ilvB1 | leuB | T45_05877 | T45_05864 | Acetolactate synthase large subunit IlvB1. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.982 |
ilvB1 | leuC | T45_05877 | T45_05822 | Acetolactate synthase large subunit IlvB1. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.895 |
ilvB1 | leuD | T45_05877 | T45_05821 | Acetolactate synthase large subunit IlvB1. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.908 |
ilvC | dat_2 | T45_05875 | T45_08372 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | D-alanine aminotransferase. | 0.445 |
ilvC | ilvB1 | T45_05875 | T45_05877 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase large subunit IlvB1. | 0.999 |