node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACK53172.1 | hisA | Tmz1t_0390 | Tmz1t_0908 | KEGG: eba:ebA6422 hypothetical protein. | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.869 |
ACK53172.1 | hisB | Tmz1t_0390 | Tmz1t_0906 | KEGG: eba:ebA6422 hypothetical protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: eba:ebA1296 imidazoleglycerol-phosphate dehydratase. | 0.869 |
ACK53172.1 | hisC | Tmz1t_0390 | Tmz1t_0905 | KEGG: eba:ebA6422 hypothetical protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: azo:azo3348 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.689 |
ACK53172.1 | hisD | Tmz1t_0390 | Tmz1t_0900 | KEGG: eba:ebA6422 hypothetical protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.869 |
ACK53172.1 | hisE | Tmz1t_0390 | Tmz1t_0911 | KEGG: eba:ebA6422 hypothetical protein. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: azo:azo3342 phosphoribosyl-ATP pyrophosphatase. | 0.869 |
ACK53172.1 | hisG | Tmz1t_0390 | Tmz1t_0899 | KEGG: eba:ebA6422 hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.869 |
ACK53172.1 | hisH | Tmz1t_0390 | Tmz1t_0907 | KEGG: eba:ebA6422 hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.976 |
ACK53172.1 | hisI | Tmz1t_0390 | Tmz1t_0910 | KEGG: eba:ebA6422 hypothetical protein. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.869 |
ACK53172.1 | hisZ | Tmz1t_0390 | Tmz1t_3380 | KEGG: eba:ebA6422 hypothetical protein. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.867 |
hisA | ACK53172.1 | Tmz1t_0908 | Tmz1t_0390 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | KEGG: eba:ebA6422 hypothetical protein. | 0.869 |
hisA | hisB | Tmz1t_0908 | Tmz1t_0906 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: eba:ebA1296 imidazoleglycerol-phosphate dehydratase. | 0.996 |
hisA | hisC | Tmz1t_0908 | Tmz1t_0905 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: azo:azo3348 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.928 |
hisA | hisD | Tmz1t_0908 | Tmz1t_0900 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisE | Tmz1t_0908 | Tmz1t_0911 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: azo:azo3342 phosphoribosyl-ATP pyrophosphatase. | 0.995 |
hisA | hisF | Tmz1t_0908 | Tmz1t_0909 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Tmz1t_0908 | Tmz1t_0899 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
hisA | hisH | Tmz1t_0908 | Tmz1t_0907 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Tmz1t_0908 | Tmz1t_0910 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Tmz1t_0908 | Tmz1t_3380 | KEGG: azo:azo3345 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.950 |
hisB | ACK53172.1 | Tmz1t_0906 | Tmz1t_0390 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: eba:ebA1296 imidazoleglycerol-phosphate dehydratase. | KEGG: eba:ebA6422 hypothetical protein. | 0.869 |