| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MICA_176 | guaA | MICA_176 | MICA_2282 | Oxidoreductase FAD-binding domain protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.589 |
| MICA_176 | hmp | MICA_176 | MICA_1640 | Oxidoreductase FAD-binding domain protein. | Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.813 |
| MICA_176 | urg1 | MICA_176 | MICA_312 | Oxidoreductase FAD-binding domain protein. | GTP cyclohydrolase II. | 0.422 |
| MICA_989 | glyA | MICA_989 | MICA_987 | nusB family protein. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.757 |
| MICA_989 | urg1 | MICA_989 | MICA_312 | nusB family protein. | GTP cyclohydrolase II. | 0.472 |
| glyA | MICA_989 | MICA_987 | MICA_989 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | nusB family protein. | 0.757 |
| glyA | guaA | MICA_987 | MICA_2282 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.781 |
| glyA | guaB | MICA_987 | MICA_2273 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.804 |
| glyA | hmp | MICA_987 | MICA_1640 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.670 |
| glyA | nadE | MICA_987 | MICA_1571 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.617 |
| glyA | upp | MICA_987 | MICA_311 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.751 |
| glyA | urg1 | MICA_987 | MICA_312 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GTP cyclohydrolase II. | 0.520 |
| guaA | MICA_176 | MICA_2282 | MICA_176 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Oxidoreductase FAD-binding domain protein. | 0.589 |
| guaA | glyA | MICA_2282 | MICA_987 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.781 |
| guaA | guaB | MICA_2282 | MICA_2273 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | mmsA | MICA_2282 | MICA_313 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Methylmalonate-semialdehyde dehydrogenase. | 0.428 |
| guaA | nadE | MICA_2282 | MICA_1571 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.755 |
| guaA | rpsB | MICA_2282 | MICA_1339 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.789 |
| guaA | upp | MICA_2282 | MICA_311 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.747 |
| guaA | urg1 | MICA_2282 | MICA_312 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase II. | 0.647 |
